The kinetics of the complex formation reaction of the UO22+ ion with a series of O and N donor ligands of Schiff bases were studied in methanol. The rate constants for the formation of UO22+ Schiff base complexes are sensitive to the structure of the Schiff base. The specific rates increase if the ligands are multidentate. Schiff bases have their donor atoms fixed in cis position and, therefore, should generally react faster than unidentate ligands. Activation parameters and pKa values of the complexes are reported.