FGF23, alpha-Klotho and vitamin D mediated calcium-phosphate metabolism in haemodialysis patients.


Paşaoğlu Ö. T. , Senelmis A., Helvaci Ö., Derici Ü., Paşaoğlu H.

Journal of medical biochemistry, vol.40, no.2, pp.160-166, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.5937/jomb0-27408
  • Journal Name: Journal of medical biochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.160-166
  • Gazi University Affiliated: Yes

Abstract

Background: Klotho is a protein that acts as a co-receptor for FGF23. FGF23-Klotho axis has great importance regarding the regulation of mineral metabolism by kidneys. In this study, we analysed FGF23, Klotho, 1,25-dihydroxyvitamin D3, 25-hydroxyvitamin D, parathormone, Calcium and Phosphate levels of haemodialysis patients in order to investigate the nature of the mineral metabolism disruption in chronic kidney diseases.