Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork

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Aktas Z., Rao H., Slauson S. R., Gabelt B. T., Larsen I. V., Sheridan R. T. C., ...Daha Fazla

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, cilt.59, sa.1, ss.298-310, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1167/iovs.17-22074
  • Dergi Adı: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.298-310
  • Anahtar Kelimeler: trabecular meshwork, FIV vector, MG132, gene therapy proteasomes, PROTEIN-KINASE INHIBITOR, DOMINANT-NEGATIVE RHOA, OUTFLOW FACILITY, GENE-TRANSFER, TRANSGENE EXPRESSION, INTRAOCULAR-PRESSURE, UVEOSCLERAL OUTFLOW, CULTURED HUMAN, OPHTHALMIC SOLUTION, ANTERIOR SEGMENTS
  • Gazi Üniversitesi Adresli: Hayır

Özet

PURPOSE: To determine if proteasome inhibition using MG132 increased the efficiency of FIV vector-mediated transduction in human trabecular meshwork (TM)-1 cells and monkey organ-cultured anterior segments (MOCAS).