No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers


van de Giessen E., Hesse S., Caan M. W. A. , Zientek F., Dickson J. C. , Tossici-Bolt L., ...More

NEUROIMAGE, vol.64, pp.61-67, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64
  • Publication Date: 2013
  • Doi Number: 10.1016/j.neuroimage.2012.09.011
  • Title of Journal : NEUROIMAGE
  • Page Numbers: pp.61-67

Abstract

Introduction: Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BM!). Striatal dopamine D-2 receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased. In this study, we tested whether BMI and striatal DAT availability are associated.