No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

van de Giessen, Elsmarieke; Hesse, Swen; Caan, Matthan; Zientek, Franziska; Dickson, John; Tossici-Bolt, Livia; Sera, Terez; Asenbaum, Susanne; Guignard, Renaud; AKDEMİR, ÜMİT; Knudsen, Gitte; Nobili, Flavio; Pagani, Marco; Borght, Thierry; Van Laere, Koen; Varrone, Andrea; Tatsch, Klaus; Booij, Jan; Sabri, Osama

doi:10.1016/j.neuroimage.2012.09.011

No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

Atıf İçin Kopyala

van de Giessen E., Hesse S., Caan M. W. A., Zientek F., Dickson J. C., Tossici-Bolt L., ...Daha Fazla

NEUROIMAGE, cilt.64, ss.61-67, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 64
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.neuroimage.2012.09.011
Dergi Adı: NEUROIMAGE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.61-67
Anahtar Kelimeler: Dopamine transporter, Striatum, Body mass index, Obesity, SPECT, [I-123]FP-CIT, NUCLEUS-ACCUMBENS, DORSAL STRIATUM, DRUG-ADDICTION, BRAIN DOPAMINE, RECEPTOR GENE, FOOD-STIMULI, RAT-BRAIN, AVAILABILITY, OBESITY, AGE
Gazi Üniversitesi Adresli: Evet

Özet

Introduction: Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BM!). Striatal dopamine D-2 receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased. In this study, we tested whether BMI and striatal DAT availability are associated.