Evaluation of ischemia after ESWL: Detection of free oxygen radical scavenger enzymes in renal parenchyma subjected to high-energy shock waves

Sarica K., Kosar A., Yaman O., Beduk Y., Durak I., Gogus O., ...More

UROLOGIA INTERNATIONALIS, vol.57, no.4, pp.221-223, 1996 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 4
  • Publication Date: 1996
  • Doi Number: 10.1159/000282918
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.221-223
  • Keywords: extracorporeal shock wave lithotripsy, free oxygen radicals, ischemia, SUPEROXIDE-DISMUTASE, LITHOTRIPSY, REPERFUSION, INHIBITION, KIDNEYS
  • Gazi University Affiliated: Yes


To evaluate the degree of ischemic formation at the tissue level after high-energy shock wave (HESW) application in a time- and dose-dependent manner, an experimental study in rabbits was performed. Following varying numbers of HESWs (1,000-2,000-3,000 shock waves) under fluoroscopic localization, treated kidneys were removed, by assessing tissue concentrations of two different free-radical scavenger enzymes (superoxide dismutase and catalase) the degree of formation of free oxygen radicals (i.e. ischemia) was evaluated. Evaluation of our results showed a statistically significant (p < 0.05) decrease in tissue scavenger enzyme levels (i.e. formation of free oxygen radicals) after 24 h following HESW application. However, results obtained 7 days after ESWL demonstrated disappearance of ischemia with normalization of tissue enzyme levels (p > 0.05).