The Effect of Probiotic Use on Some Blood Parameters in Overweight and Obese Women Who Follow a-Loss Diet

Orak Y. I. , Bulduk S., Bastemir M.

PROGRESS IN NUTRITION, vol.24, no.3, 2022 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.23751/pn.v24i3.13113
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Keywords: weight-loss diet, overweight, obesity, probiotic, body composition, GUT MICROBIOTA, DOUBLE-BLIND, NUTRITION, HEALTH
  • Gazi University Affiliated: Yes


Background and aim: This study was conducted to determine the effect of 8-week probiotic use on body composition and blood parameters in overweight and obese women who are on a weight loss diet Methods: 34 women with a BMI value above 25 kg/m2 participated. The individuals participating in the re-search were divided into two groups. For eight weeks, the experimental group was given a weight loss diet pro-gram, exercise program and oral probiotic nutritional supplement containing various probiotic strains in the amount of 1.5x109 cfu/g in each capsule twice a day; The control group was given a weight loss diet program and an exercise program without probiotic supplementation. Anthropometric measurements of the individu-als (height baseline, body weight, waist, hip and neck circumference, body mass index, waist/hip circumference and waist-height ratio) in both groups were evaluated statistically at the initial, 4th and 8th weeks. Some bio-chemical parameters were measured at the beginning of the study and the end of the 8th week. Results: A sig-nificant difference was found between body weight, body mass index, waist circumference, hip circumference, waist-height ratio, body fat percentage, and body fat mass measurements (p<0,001). Significant improvements were found in LDL-C, fasting insulin, AST and TSH values in both groups (p<0.05). While the HOMA-IR values were significantly lower, HDL-C values were found to be significantly higher at the end of the study in the experimental group (p<0.05). Conclusions: Balanced hypocaloric diet caused significant improvements in anthropometric measurements and blood parameters in experimental and control groups. The use of probiot-ics has positive effects on HOMA-IR and HDL-C values in the experimental group.