Immunohistochemical expression of beta-catenin, E-cadherin, cyclin D1 and c-myc in benign trichogenic tumors


Demirkan N. C. , Bir F., ERDEM O. A. , Duzcan E.

JOURNAL OF CUTANEOUS PATHOLOGY, cilt.34, sa.6, ss.467-473, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1600-0560.2006.00636.x
  • Dergi Adı: JOURNAL OF CUTANEOUS PATHOLOGY
  • Sayfa Sayıları: ss.467-473

Özet

Background: beta-catenin gene mutations have been reported in vast majority of pilomatrixomas (PMXs). P-catenin, a component of the adhesion molecules of the cytoskeleton, is degraded at the cytoplasm. Excess cytoplasmic beta-catenin enters into the nucleus and activates the transcription of several genes encoding c-myc, cyclin D1 and others. Sublocation of beta-catenin has been demonstrated by immunohistochemistry. The aim of this study was to determine the role of P-catenin-related proteins in various benign trichogenic tumors.