The in vitro hepatic metabolism of 1-phenyl-2-(2-benzothiazolinone-3-yl)ethanone and their reduced derivatives


Yilmaz F., Ulgen M., DOĞRUER D. S. , Cakir B., Sahin M.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol.51, pp.442-445, 1999 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 1999
  • Doi Number: 10.1016/s0940-2993(99)80037-2
  • Title of Journal : EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Page Numbers: pp.442-445

Abstract

The in vitro hepatic microsomal metabolism of 1-phenyI-2- (2-benzothiazolinone-3 -yl)ethanone (I) and (9)-1-Phenyl-2-(2-benzothiazolinone-3-yl)ethanol (II)) was studied using both rat microsomal preparations and soluble fractions fortified with NADPH. These two substrates and their potential dealkylation metabolite 2-benzothiazoIinone were synthesized and their structures were elucidated by spectral methods.