The in vitro hepatic metabolism of 1-phenyl-2-(2-benzothiazolinone-3-yl)ethanone and their reduced derivatives

Yilmaz, F; Ulgen, M; DOĞRUER, DENİZ; Cakir, B; Sahin, MF

doi:10.1016/s0940-2993(99)80037-2

The in vitro hepatic metabolism of 1-phenyl-2-(2-benzothiazolinone-3-yl)ethanone and their reduced derivatives

Atıf İçin Kopyala

Yilmaz F., Ulgen M., DOĞRUER D. S., Cakir B., Sahin M.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, cilt.51, ss.442-445, 1999 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 51
Basım Tarihi: 1999
Doi Numarası: 10.1016/s0940-2993(99)80037-2
Dergi Adı: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.442-445
Gazi Üniversitesi Adresli: Evet

Özet

The in vitro hepatic microsomal metabolism of 1-phenyI-2- (2-benzothiazolinone-3 -yl)ethanone (I) and (9)-1-Phenyl-2-(2-benzothiazolinone-3-yl)ethanol (II)) was studied using both rat microsomal preparations and soluble fractions fortified with NADPH. These two substrates and their potential dealkylation metabolite 2-benzothiazoIinone were synthesized and their structures were elucidated by spectral methods.