Intracardiac Thrombus in Children: The Fine Equilibrium Between the Risk and the Benefit


ÇETİN İ. İ. , Ekici F., Unal S., Kocabas A., Sahin S., Yazici M., ...More

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.31, no.5, pp.481-487, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.3109/08880018.2014.919546
  • Journal Name: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.481-487
  • Keywords: algorithm, children, intracardiac thrombus, risk factors, treatment, MOLECULAR-WEIGHT HEPARIN, PROSPECTIVE COHORT, PEDIATRIC-PATIENTS, PREMATURE-INFANTS, MANAGEMENT, CHILDHOOD, THERAPY, DISEASE
  • Gazi University Affiliated: No

Abstract

The medical records of 16 patients diagnosed as intracardiac thrombus were searched. The size, location and outcome of thrombus together with demographic data of patients were assessed. The median age of the patients was 2.2 years. Six patients were newborn and two patients were infant. The median size of thrombus was 9 mm. The localization was right atrium in seven, right ventricle in five, left ventricle in one, pulmonary artery in one, and superior vena cava in two patients. There was prematurity in five, ciyanotic congenital heart disease in one, blood culture positivity in three, malignancy in four, nephrotic syndrome in one, indwelling catheters in 10, and acquired or genetic thrombophilia in six patients as risk factors. In the treatment, the first choice was tissue plasminogen activator in two patients, heparin infusion in one patient and low molecular weight heparin in remaining 12 patients. In nine patients, therapy included parenteral antimicrobials together with anticoagulants. The result was complete resolution in 15 patients and in one patient thrombus was surgically removed. The median time was 16 (2-70) days for 50% resolution and 26 (3-93) days for complete resolution. There was a statistically significant (P = .027 and r = 0.5) correlation between the size and the complete resolution time. There was no anticoagulant therapy related major complication. In patients with intracardiac thrombus, selection of anticoagulant therapy may decrease the risk of complications. Surgery is rarely required and thrombolytics are not usually necessary for resolution of thrombus.