Effects of quercetin on chronic constriction nerve injury in an experimental rat model

Civi S., EMMEZ G., Dere U. A., BÖRCEK A. Ö., Emmez H.

ACTA NEUROCHIRURGICA, cilt.158, sa.5, ss.959-965, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 158 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00701-016-2761-0
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.959-965
  • Anahtar Kelimeler: Chronic constriction injury, Flavonoids, Neuropathic pain, Quercetin, NEUROPATHIC PAIN MODEL, SPINAL-CORD-INJURY, FLAVONOIDS, HYPERALGESIA, ANTIOXIDANTS, INFLAMMATION, GABAPENTIN, RELEASE, PATHWAY, MOUSE
  • Gazi Üniversitesi Adresli: Evet

Özet

Flavonoids are popular substances in the literature, with proven effects on cardiovascular, neoplastic and neurodegenerative diseases. Antioxidant effect is the most pronounced and studied one. Among thousands of flavonoids, quercetin (QUE) is a prototype with significant antioxidant effects. This study aims to demonstrate the effects of QUE in an experimental rat model of chronic constriction injury (CCI).