In this study; involvement of sympathetic nervous system in stroke patients was investigated. Nineteen patients, whose mean age was 52.9 ± 14.0 years, were included in the study. Sympathetic skin responses (SSR) were used to assess sympathetic nervous system and results were compared with control group. Mean SSR latency was 1.41 ± 0.07 msec for the upper extremity, 1.94 ± 0.10 msec for the lower extremity in the control group. In the patient group mean SSR latencies were 1.45 ± 0.10 msec for the hemiplegic, 1.36 ± 0.19 msec for the unaffected upper extremities, and the latencies for the lower extremities were 2.14 ± 0.44 msec and 1.99 ± 0.38 msec, respectively. Mean SSR latencies of the upper and lower extremities for the patient and control groups were not different between the groups. There was significant correlation between time since onset of stroke and SSR latencies of the hemiplegic upper extremity (r:-0.57). Mean SSR latencies of hemiplegic limbs were longer than the unaffected ones, but the difference was statistically significant only in the upper extremities (p=0.01). Sympathetic skin responses were absent in bilateral lower extremities of 2 patients. Sympathetic skin response latencies were 2 standart deviations above the normal mean values in hemiplegic upper limb of 7 patients, unaffected upper limb of 4 patients, hemiplegic lower limb of 5 patients and unaffected lower limb of 4 patients. Our results demonstrated that sympathetic nervous system might be involved after cerebrovascular accident.