Is bacterial vaginosis associated with a pro-inflammatory cytokine profile in endometrial secretions of women undergoing IVF?

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Boomsma C. M., Kavelaars A., BOZKURT N., Eijkemans M. J. C., Fauser B. C. J. M., Heijnen C. J., ...Daha Fazla

REPRODUCTIVE BIOMEDICINE ONLINE, cilt.21, sa.1, ss.133-141, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.rbmo.2010.03.022
  • Dergi Adı: REPRODUCTIVE BIOMEDICINE ONLINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.133-141
  • Anahtar Kelimeler: bacterial vaginosis, endometrial secretion, IVF, pro-inflammatory cytokines, IN-VITRO FERTILIZATION, TUMOR-NECROSIS-FACTOR, EMBRYO-TRANSFER, PREGNANT-WOMEN, PROINFLAMMATORY CYTOKINES, ASSISTED REPRODUCTION, VAGINAL FLUID, HUMAN DECIDUA, IMPLANTATION, INFERTILITY
  • Gazi Üniversitesi Adresli: Evet

Özet

The objective of this prospective cohort study was to elucidate whether bacterial vaginosis (BV) is associated with a proinflammatory endometrial secretion cytokine profile and whether there is a relationship between BV and the concentrations of a number of key regulatory cytokines, chemokines and growth factors. A total of 198 women undergoing IVF treatment were included. Prior to embryo transfer, participants underwent screening for BV according to Nugent criteria by a Gram-stained cervical smear. The concentrations of 17 soluble mediators of human implantation were measured by multiplex immunoassay in endometrial secretions aspirated prior to embryo transfer. Seventeen (8.6%) women had BV (Nugent score >6). Multivariable logistic regression showed a significant positive association between interleukin-beta and the presence of BV (P = 0.011; Nugent score >6 versus <= 6) and a significant negative association between eotaxin and BV (P=0.003). No significant differences were found in the ratios of distinct pro- and anti-inflammatory cytokines in endometrial secretions from women with or without BV. In conclusion, BV is associated with higher concentrations of interleukin-beta in endometrial secretions compared with women without BV. However, no distinct difference in pro- and anti-inflammatory profiles is present. An effect on endometrial receptivity is unlikely. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.