Serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in obese children


Bideci A., Cinaz P., Hasanoglu A., Elbeg S.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.10, no.3, pp.295-299, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 3
  • Publication Date: 1997
  • Doi Number: 10.1016/s0026-0495(97)90071-8
  • Title of Journal : JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Page Numbers: pp.295-299
  • Keywords: obesity, children, insulin-like growth factor-I, insulin-like growth factor binding protein-3, HORMONE-RELEASING FACTOR, SOMATOMEDIN-C LEVELS, SECRETION, PLASMA, DISORDERS, PUBERTY, GIRLS

Abstract

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) metabolism may be disturbed in obese children. We investigated serum GH, IGF-I, IGF-binding protein-3 (IGFBP-3) levels in 42 obese and 40 non-obese healthy children aged 6-14 years. GH stimulation tests with L-dopa and insulin were performed. Serum IGF-I levels were studied by immunoradiometric assay (IRMA) and IGFBP-3 levels by radioimmunoassay (RIA). IGF-I levels were significantly higher in the obese group (p < 0.05), but IGFBP-3 levels were not different from the control group. IGF-I and IGFBP-3 levels were significantly higher in the obese pubertal children than in the obese prepubertal ones (p < 0.05). A positive linear correlation was found between body mass index (BMI) and IGF-I levels (r = 0.51, p < 0.05). These results suggest that obesity may have a considerable effect on IGF-I.