Investigation of ototoxic effects of taxol on a mice model

Ahmet A., Orhan A., Sarp S., Poyraz A., Akyol M.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, cilt.70, sa.5, ss.779-784, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 5
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.ijporl.2005.11.011
  • Dergi Adı: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.779-784
  • Anahtar Kelimeler: taxol, paclitaxel, ototoxicity, sensorineural hearing loss, animal experiment, ADVANCED OVARIAN-CANCER, NEUROLOGICAL ELEMENTS, RABBIT COCHLEA, PHASE-II, PACLITAXEL, CISPLATIN, CHEMOTHERAPY, VINCRISTINE, CARBOPLATIN, NEUROPATHY
  • Gazi Üniversitesi Adresli: Hayır

Özet

Objective: To investigate the effects of taxol on the inner ear in a mice model. Methods: This study was performed on 112 ears of 56 albino Swiss mice. All animals underwent baseline auditory brainstem response (ABR) testing bilaterally and baseline Peak Equivalent Sound Pressure Levels (PESPLs) were obtained. The mice were randomly assigned to seven groups consisting of one control and six study groups. The control group received no medications while the mice in groups 1-6 received 1 x 60, 1 x 20, 2 x 20, 3 x 20, 4 x 20 and 5 x 20 mg/kg taxot intraperitoneatly. Control ABR assessments were performed 3 weeks after the last dose. The animals were then sacrificed while still anaesthetised and the bullae (cochleae included) were dissected from their temporal bones. Haematoxylin-eosin and Masson's trichrome stains were used to demonstrate connective tissue, and periodic acid Schiff (PAS) stain was used to highlight epithelial elements.