Association of the -1438G/A polymorphism of the 5-HT2A receptor gene with obstructive sleep apnea syndrome.


Bayazit Y., Yilmaz M., Ciftci T., Erdal E., Kokturk O., Gokdogan T., ...Daha Fazla

ORL; journal for oto-rhino-laryngology and its related specialties, cilt.68, sa.3, ss.123-8, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1159/000091216
  • Dergi Adı: ORL; journal for oto-rhino-laryngology and its related specialties
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.123-8
  • Anahtar Kelimeler: serotonergic system, 5-HT2A receptor, sleep apnea, SEROTONIN RECEPTOR, T102C POLYMORPHISM, MIGRAINE, RATS
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Serotonergic neurons innervating motoneurons increase their firing rates in response to respiratory challenges, and long-term facilitation of respiratory activity in response to hypoxia is serotonin (5-HT) dependent. Polymorphism of the genes which code for 5-HT receptors may affect functions of the serotonergic system, and may be associated with obstructive sleep apnea syndrome (OSAS). The objective in this study was to assess the significance of T102C and -1438G/A polymorphisms of the 5-HT2A receptor gene in OSAS. Methods: Fifty-five patients with OSAS and 102 healthy volunteers were included for genetic analyses of T102C and -1438G/A polymorphisms of the 5-HT2A receptor gene. Results: For the T102C polymorphism, there was no significant difference between the patients and controls and both genders (p > 0.05). For the -1438G/A polymorphism, the A/A and G/A genotypes were overrepresented in the patients and controls, respectively (p = 0.045). In the control group, the genotypes of both genders were not significantly different (p > 0.05). In the patients, the A/A and G/A genotypes were overrepresented in males and females, respectively (p = 0.035). Concerning males, the A/A genotype was overrepresented in patients (p = 0.007). Conclusion: Serotonergic mechanisms appear to be related to OSAS. The T102C polymorphism of the 5-HT2A receptor gene is not associated with OSAS. However, the -1438G/A polymorphism is associated with OSAS occurrence, especially in male patients. This polymorphism may also be associated with different OSAS incidences of both genders.