Flow cytometric DNA analysis, and immunohistochemical p53, PCNA and histopathologic study in primary achalasia: preliminary results.

Bektas A., Yasa M., Kuzu I., Dogan İ., ÜNAL S., Ormeci N.

Hepato-gastroenterology, vol.48, no.38, pp.408-12, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 38
  • Publication Date: 2001
  • Journal Name: Hepato-gastroenterology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.408-12
  • Gazi University Affiliated: Yes

Abstract

Background/Aims: Primary achalasia Is a premalignant disorder of the esophagus. The studies for esophageal cancer pathogenesis may reveal early diagnosis of esophageal cancer. DNA aneuploidy, p53 mutations and cellular proliferation are important factors in cancer development. As far as we know, we have not encountered any study on these factors in achalasia.