Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In-Silico-Based Future Therapeutic Potential

Boualam K., Ortaakarsu A. B., Khatib S., Farag M. A., Sobeh M.

eFood, vol.7, no.3, 2026 (ESCI, Scopus) identifier identifier

  • Publication Type: Article / Review
  • Volume: 7 Issue: 3
  • Publication Date: 2026
  • Doi Number: 10.1002/efd2.70128
  • Journal Name: eFood
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Keywords: biosynthesis, cubebene, cubebol, cubenol, pharmacological activities, Shisandra chinensis, therapeutic application
  • Gazi University Affiliated: Yes

Abstract

Cubebenes and related sesquiterpenes, a diverse subclass of terpenes, exhibit remarkable structural complexity and significant pharmacological potential. These naturally occurring compounds, found across various plant species and biological kingdoms, play crucial ecological and medicinal roles. This review presents a compilation of their natural terrestrial and marine sources, biosynthesis, extraction methods, and pharmacological properties, emphasizing their antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. Additionally, a bibliometric assessment, combined with computational tools, uncovers research trends, identifies gaps, and predicts potential therapeutic applications, offering valuable insights for future studies on these versatile natural products.