Increased expression of cyclooxygenase-2 (COX-2) in radiation-induced small bowel injury in rats


Keskek M., Gocmen E., Kilic M., Gencturk S., Can B., Cengiz M., ...More

JOURNAL OF SURGICAL RESEARCH, vol.135, no.1, pp.76-84, 2006 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 135 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1016/j.jss.2006.03.031
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.76-84

Abstract

Background. Radiation therapy is a widely used adjuvant therapy for various abdominal and pelvic cancers. On the other hand, it is not a benign treatment modality, as most radiation patients suffer from some kind of radiation enteritis. Currently available treatments are only palliative and no ideal compound has as yet been discovered. The aim of this study was to evaluate cyclooxygenase-2 (COX-2) expression, and to investigate the possible protective effect of the selective COX-2 inhibitor, Rofecoxib, in acute and late stages of radiation-induced intestinal injury in rats.