To estimate association of depression and anxiety scores with oocyte and sperm numbers and pregnancy rates during in vitro fertilization (IVF) treatment, 80 Turkish couples were administered the Spielberger State and Trait Anxiety and Beck Depression Inventories. A significant correlation (r = -.25) obtained between Depression and women's oocyte pickup data and number of oocytes, showed that low oocyte numbers were associated with higher Depression. No significant relation was found for sperm counts with Anxiety and Depression scores on the day of oocyte pickup and sperm collection, but sperm motility was weakly and inversely correlated with Depression scores. Women with high State Anxiety score on the oocyte pickup day had significant lower pregnancy rates, as did those with higher Depression. Counseling of couples by health professionals on fertility-related issues to be implemented in IVF units is advisable.