Application of Toxicological Data for Chemical Risk Management in Food Safety; TTC Approach

Creative Commons License

Karahalil B.

JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, vol.10, no.11, pp.3-8, 2022 (Peer-Reviewed Journal)

  • Publication Type: Article / Review
  • Volume: 10 Issue: 11
  • Publication Date: 2022
  • Journal Indexes: Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts
  • Page Numbers: pp.3-8
  • Gazi University Affiliated: Yes


Abstract Advances in analytical techniques emerged the chemical contaminants risks that exist for many years, although they are not known. In food safety, the starting point of risk management of contaminants is the toxicological data. The effective use of risk analysis methodologies based on these data can help the protection of human health. The starting point of the methodologies used in the management of contaminants in foods is whether the contaminants are genotoxic or not. For non-genotoxic chemicals, nonthreshold risk management method and for genotoxic chemicals, threshold method is applied. Due to the production of new chemicals, every day and as the number of these chemicals reached up to hundreds, a bottleneck in the production of toxicity data has been appeared. To solve this problem, threshold toxicological concern (TTC) is developed for the chemical contaminants whose chemical structures are known but exposure to them is below the certain amounts. Additionally, toxicological data that will contribute to the preparations of the regulations for the future new risks, such as nanofoods, have been started to be produced. Keywords: Food Safety; TTC Approach; Cramer Decision Tree; Nanotechnology; Risk Management