Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin


Kupeli E., Orhan İ. , Toker G., Yesilada E.

Journal of Ethnopharmacology, cilt.107, ss.169-174, 2006 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 107 Konu: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jep.2006.02.021
  • Dergi Adı: Journal of Ethnopharmacology
  • Sayfa Sayıları: ss.169-174

Özet

The aqueous, ethanolic and chloroform extracts and two prenylated isoflavones: scandenone (I) and auriculasin (II), isolated from the fruits of Maclura pomifera (Rafin.) Schneider, were investigated for their in vivo anti-inflammatory and antinociceptive activity. For the anti-inflammatory activity, both carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Scandenone, the chloroform and the ethanolic extracts were shown to possess antinociceptive activity and anti-inflammatory activity on carrageenan-induced hind paw edema model at 100 mg/kg dose. The same compound and the extract were also found to be highly active in (TPA)-induced mouse ear edema model whereas auriculasin and the H2O extract showed to be inactive in all of the assays. © 2006 Elsevier Ireland Ltd. All rights reserved.