Gazi Sağlık Bilimleri Enstitüsü Dergisi GUHES, vol.2, pp.28-35, 2020 (Peer-Reviewed Journal)
Autism spectrum disorder (ASD); It is an extremely heterogeneous neurodevelopmental disorder that occurs in early childhood. Although the number of cases of Autism diagnosed during the last four decades has increased significantly, there is still considerable debate about the underlying pathophysiology of ASD. The aim of this retrospective study was to evaluate the biochemical blood parameters of children with autism.The study included 30 children with autism aged between 10 and 18 years and 30 healthy children as a control group. The autism group was selected from the children with autism diagnosis in the Department of Pediatric Neurology at Gazi University Faculty of Medicine between 2018-2019 and the control group was selected from the Children's Health Unit. Control group; was selected from patients who were in the same age range as the autism group and who did not have any neurological disease. For the study, the ethics committee permission was obtained from the meeting on 28.05.2018 (decision number: 430) from Gazi University Clinical Research Ethics Committee. In two groups, routine biochemical parameters were evaluated retrospectively. Autism is now seen that it affects 1% of the world's population and disproportionately affects men According to the our study, the ratio of boys to girls was 1,5 in children with autism and 0,87 in the control group. The difference between vitamin 25-OHD (μg/L) levels of autism and control group was statistically significant p = 0,025 (p<0,05). We believe that randomized controlled trials using adequate doses of vitamin D3 are necessary in children with autism, and that further studies on nutritional disorders and behavioral problems, metabolic differences, and biomarkers are necessary.