Arginine-Nitric Oxide-Polyamine Metabolism in Periodontal Disease

Ozer L., Elgun S., Özdemir B., Pervane B., Özmeriç Kurtuluş N.

JOURNAL OF PERIODONTOLOGY, cilt.82, sa.2, ss.320-328, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 82 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1902/jop.2010.100199
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.320-328
  • Anahtar Kelimeler: Arginase, nitric oxide, ornithine decarboxylase, periodontal diseases, HUMAN GINGIVAL FIBROBLASTS, ORNITHINE DECARBOXYLASE, TISSUE DESTRUCTION, ARGINASE ACTIVITY, MESSENGER-RNA, SALIVA, EXPRESSION, SYNTHASE, THERAPY
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Arginine is converted to nitric oxide (NO) via NO synthase and to ornithine via arginase. Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to polyamines. Arginase can inhibit NO production, and NO can inhibit ODC activity as part of an early inflammatory response. This study examines the arginine-NO-polyamine pathway alteration in saliva and gingival biopsy samples of patients with gingivitis or periodontitis and healthy controls and evaluates the response to periodontal treatment.