Arginine-Nitric Oxide-Polyamine Metabolism in Periodontal Disease

Ozer L., Elgun S., Özdemir B., Pervane B., Özmeriç Kurtuluş N.

JOURNAL OF PERIODONTOLOGY, vol.82, no.2, pp.320-328, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1902/jop.2010.100199
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.320-328
  • Keywords: Arginase, nitric oxide, ornithine decarboxylase, periodontal diseases, HUMAN GINGIVAL FIBROBLASTS, ORNITHINE DECARBOXYLASE, TISSUE DESTRUCTION, ARGINASE ACTIVITY, MESSENGER-RNA, SALIVA, EXPRESSION, SYNTHASE, THERAPY
  • Gazi University Affiliated: Yes

Abstract

Background: Arginine is converted to nitric oxide (NO) via NO synthase and to ornithine via arginase. Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to polyamines. Arginase can inhibit NO production, and NO can inhibit ODC activity as part of an early inflammatory response. This study examines the arginine-NO-polyamine pathway alteration in saliva and gingival biopsy samples of patients with gingivitis or periodontitis and healthy controls and evaluates the response to periodontal treatment.