Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF


Creative Commons License

Pekel A., GÖNENÇ A., Turhan N. O. , Kafali H.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, vol.32, no.2, pp.233-241, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1007/s10815-014-0396-8
  • Journal Name: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.233-241
  • Keywords: sFas, sFasL, Oxidative stress, Antioxidant, IVF, IN-VITRO FERTILIZATION, SOLUBLE FAS LIGAND, SUPEROXIDE-DISMUTASE, ASSISTED REPRODUCTION, ANTIOXIDANT CAPACITY, WOMEN, APOPTOSIS, OXYGEN, ENDOMETRIOSIS, INFERTILITY
  • Gazi University Affiliated: Yes

Abstract

The Fas-Fas Ligand interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of infertility causing diseases in women and has been suggested as one of the important factors that negatively affect IVF outcome. In this study, our aim was to evaluate serum and follicular fluid levels of soluble Fas soluble Fas Ligand, malondialdehyde, superoxide dismutase and total antioxidant capacity in patients undergoing IVF and compared with controls.