Akademik Veri Yönetim Sistemi
Ondokuz Mayis Universitesi Tip Dergisi, cilt.25, sa.4, ss.131-138, 2008 (Scopus)
Poor ovarian response is a major factor limiting success in assisted reproduction. There is currently no agent or protocol that has been unequivocally proven to be successful in patients with poor ovarian response. Our objective in this study was to compare stop-leuprolide acetate and luteal long-leuprolide acetate protocols with using high dose recombinant follicule stimulating hormone. 19 patients with previous poor ovarian response during intracytoplasmic sperm injection cycle were included. Patient were randomized with computer produced numbers to luteal long-leuprolide acetate(n=8) and stop-leuprolide acetate (n=11). Recombinant follicule stimulating hormone was started on day three with starting dose of 450IU/day and the dose was induvidualized using step-down regimen. All patients had similar intracytoplasmic sperm injection cycle, embryo transfer and luteal support procedures Both groups were comparable in terms of body mass index, female age, duration of infertility. All paremeters of ovarian response gonodotrophin dose, time reguired for stimulation, cancellation rate, number of mature oocytes and transfered embrios were comparable between two groups. None of the patients in the stop-leuprolide acetate exhibited a premature LH surge. We could not have any pregnancies in both groups. We conclude that stop-leuprolide acetate protocol and luteal long-leuprolide acetate protocol have similar effect on ovarian response in poor responders. We did not observe any premature LH surge in the stop-leuprolide acetate group.