Dietary Fructose-Induced Hepatic Injury in Male and Female Rats: Influence of Resveratrol

PEKTAŞ M. B. , Yucel G., KOCA H. B. , SADİ G., Yildirim O. G. , Ozturk G., ...More

DRUG RESEARCH, vol.67, no.2, pp.103-110, 2017 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1055/s-0042-118386
  • Title of Journal : DRUG RESEARCH
  • Page Numbers: pp.103-110


Purpose: Relatively little is known about gender-dependent susceptibility to hepatic injury induced by nutritional factors. In the current study, we investigated dietary fructose-induced hepatic degeneration and roles of endothelial nitric oxide synthase (eNOS), insulin receptor (IR beta) and substrate-1 (IRS-1) expressions in association with inflammatory markers in male and female rats. Moreover, we examined potential effect of resveratrol on fructose-induced changes.