Dietary Fructose-Induced Hepatic Injury in Male and Female Rats: Influence of Resveratrol

PEKTAŞ M. B. , Yucel G., KOCA H. B. , SADİ G., Yildirim O. G. , Ozturk G., ...Daha Fazla

DRUG RESEARCH, cilt.67, sa.2, ss.103-110, 2017 (ESCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Konu: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1055/s-0042-118386
  • Dergi Adı: DRUG RESEARCH
  • Sayfa Sayıları: ss.103-110


Purpose: Relatively little is known about gender-dependent susceptibility to hepatic injury induced by nutritional factors. In the current study, we investigated dietary fructose-induced hepatic degeneration and roles of endothelial nitric oxide synthase (eNOS), insulin receptor (IR beta) and substrate-1 (IRS-1) expressions in association with inflammatory markers in male and female rats. Moreover, we examined potential effect of resveratrol on fructose-induced changes.