A rapid and specific proton magnetic resonance (PMR) spectroscopic method was developed for determining ranitidine hydrochloride in tablets. 2-Choloroacetophenon was used as the internal standard and DMSO-d(6) served as the PMR solvent. The concentration of drug per unit dose was calculated from the integration values for the resonance signals of ranitidine hydrochloride at 4.32 delta ppm and int. st. at 5.19 delta ppm. The method using commercial products gave comparable results to those obtained by the methods of UV spectroscopy and USP XXIII.