Quantitative proton magnetic resonance analysis of ranitidine in solid dosage forms


Ozden T., Ungormus A., Tosun A., Ersan S.

SPECTROSCOPY LETTERS, vol.30, no.5, pp.835-841, 1997 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 5
  • Publication Date: 1997
  • Doi Number: 10.1080/00387019708001632
  • Journal Name: SPECTROSCOPY LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.835-841
  • Gazi University Affiliated: No

Abstract

A rapid and specific proton magnetic resonance (PMR) spectroscopic method was developed for determining ranitidine hydrochloride in tablets. 2-Choloroacetophenon was used as the internal standard and DMSO-d(6) served as the PMR solvent. The concentration of drug per unit dose was calculated from the integration values for the resonance signals of ranitidine hydrochloride at 4.32 delta ppm and int. st. at 5.19 delta ppm. The method using commercial products gave comparable results to those obtained by the methods of UV spectroscopy and USP XXIII.