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ENGİN A. B., ENGİN A.
PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH, vol.1275, pp.285-321, 2021 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
1275
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Publication Date:
2021
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Doi Number:
10.1007/978-3-030-49844-3_11
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Journal Name:
PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
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Page Numbers:
pp.285-321
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Keywords:
Alzheimer's disease (AD), N-methyl-D-aspartate receptor (NMDAR), Amyloid precursor protein (APP), Amyloid beta (Abeta), Tau, Abeta-derived diffusible ligand (ADDL), Ephrin B receptor, Cytosolic p21-activated kinase (PAK), Neurofibrillary tangle (NFT), Type 3 diabetes, AMYLOID PRECURSOR PROTEIN, BRAIN INSULIN-RESISTANCE, INFLAMMATORY MICROGLIAL ACTIVATION, EXTRASYNAPTIC NMDA RECEPTORS, TRANS-GOLGI NETWORK, A-BETA, OXIDATIVE STRESS, MOUSE MODEL, TAU-PROTEIN, NEUROTROPHIC FACTOR
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Gazi University Affiliated:
Yes
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disorder and accounts for more than 60-80% of all cases of dementia. Loss of pyramidal neurons, extracellular amyloid beta (Abeta) accumulated senile plaques, and neurofibrillary tangles that contain hyperphosphorylated tau constitute the main pathological alterations in AD.