Alzheimer's Disease and Protein Kinases

ENGİN A. B., ENGİN A.

PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH, vol.1275, pp.285-321, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1275
  • Publication Date: 2021
  • Doi Number: 10.1007/978-3-030-49844-3_11
  • Journal Name: PROTEIN KINASE-MEDIATED DECISIONS BETWEEN LIFE AND DEATH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.285-321
  • Keywords: Alzheimer's disease (AD), N-methyl-D-aspartate receptor (NMDAR), Amyloid precursor protein (APP), Amyloid beta (Abeta), Tau, Abeta-derived diffusible ligand (ADDL), Ephrin B receptor, Cytosolic p21-activated kinase (PAK), Neurofibrillary tangle (NFT), Type 3 diabetes, AMYLOID PRECURSOR PROTEIN, BRAIN INSULIN-RESISTANCE, INFLAMMATORY MICROGLIAL ACTIVATION, EXTRASYNAPTIC NMDA RECEPTORS, TRANS-GOLGI NETWORK, A-BETA, OXIDATIVE STRESS, MOUSE MODEL, TAU-PROTEIN, NEUROTROPHIC FACTOR
  • Gazi University Affiliated: Yes

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder and accounts for more than 60-80% of all cases of dementia. Loss of pyramidal neurons, extracellular amyloid beta (Abeta) accumulated senile plaques, and neurofibrillary tangles that contain hyperphosphorylated tau constitute the main pathological alterations in AD.