<p>Ultrasound/redox/pH-responsive hybrid nanoparticles for triple-triggered drug delivery</p>


Demirel G. B. , Bayrak S.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol.71, 2022 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 71
  • Publication Date: 2022
  • Doi Number: 10.1016/j.jddst.2022.103267
  • Title of Journal : JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Keywords: Drug delivery, Cancer, pH-sensitivity, Redox-triggered, Ultrasound triggered, MESOPOROUS SILICA NANOPARTICLES, MODIFIED GOLD NANOPARTICLES, INTRACELLULAR DRUG, MAGNETIC NANOPARTICLES, POLYMERIC MICELLES, CHARGE-REVERSAL, LIPOIC ACID, RELEASE, NANOCARRIERS, DOXORUBICIN

Abstract

We have developed a triple pH/redox/ultrasound-triggered hybrid nanocarrier system for controlled drug de-livery. This multifunctional hybrid system was synthesized as a core/shell nanoparticle consisting of mesoporous silica coated magnetic core (Fe3O4@SiO2@mSiO(2)) and pH/redox-responsive polymer layer. We synthesized lipoic acid (LA)-conjugated chitosan (CS) polymer as pH/redox-responsive polymer (CS-LA) layer of the particles. Then the synthesized ellipsoidal Fe3O4@SiO2@mSiO(2) nanoparticles were coated by CS-LA polymer. To prepare triple-responsive release system, the LA components of the CS-LA polymer layer were crosslinked by DTT. The results showed that the hybrid nanoparticles exhibited an efficient DOX release in cellular pH environment. In addition, the dual pH/redox-responsive drug release results exhibited that the hybrid nanoparticles showed an efficient and controlled drug release profile in the presence of 10 mM GSH at pH = 5.5 at 37 ?& nbsp;within 24 h. Ultrasound (US)-induced release profile of the hybrid nanoparticles showed that the DOX release behaviour was controlled effectively by US-triggered. In vitro cytotoxicity tests exhibited that DOX loaded hybrid nanoparticles provide an efficient cell death in MCF-7 cells at pH = 5.5. In our belief, these triple-triggered hybrid nano-particles have promising potential for controlled drug release and are worth doing further in vivo research.