Attention deficit hyperactivity disorder and anti-Purkinje autoantibodies: no link?

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ÇETİN F. H., Cetin F., Isik Y., GÜNEY E., Alp F., Aksoy A.

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.29, no.4, pp.435-440, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1080/24750573.2018.1517467
  • Journal Name: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.435-440
  • Keywords: Attention deficit hyperactivity disorder, Anti-Yo, Anti- Hu, Anti-Ri, neuroinflammation, cerebellum, DEFICIT/HYPERACTIVITY DISORDER, CEREBELLUM, CHILDREN, TEACHER, PREDICTION, PARENT
  • Gazi University Affiliated: Yes

Abstract

OBJECTIVES: Attention Deficit Hyperactivity Disorder (ADHD) is a neurobehavioral disorder that begins in early childhood, and many factors play role in its etiology. Many studies have been conducted to identify the causes of ADHD, but the exact factors are still unknown. Although cerebellar dysfunction in the etiology of ADHD was shown in different studies, the possible causes of dysfunction and the role of neuroinflammation among these causes has not been clarified yet. Anti-Yo is an antibody against the antigens in the cytoplasm of purkinje cells and indicates cerebellar degeneration, and Anti-Hu and Anti-Ri are antibodies against cellular nuclear antigens of purkinje cells. This study aimed to evaluate the role of neuroinflammation that is a potential cause of cerebellar dysfunction, which is thought to be an important factor in the development of ADHD.