© 2022 A. CARBONE Editore. All rights reserved.Background: Helicobacter pylori (HP) is one of the most common chronic infections in the world. Cardiovascular diseases are the leading causes of morbidity and mortality in industrialized countries. The major cause of death in diabetic patients is atherosclerosis due to dyslipidemia. The effect of such a common infection on dyslipidemia and atherosclerosis in diabetics must be analyzed. The aim of this study was to investigate the impact of HP presence and severity to the lipid profile in diabetic patients. Materials and methods: This retrospective cross-sectional study was carried out on 240 diabetic patients between 25-95 years, who were following up by Diabetes Policlinic of GOP Education and Research Hospital and who had undergone gastroscopy with biopsy from 2015 to 2017, which was evaluated regard to HP histopathologically by Updated Sydney System score. Patients were divided into 2 groups firstly: HP negative (n=120) and HP positive (n=120) ones. Then HP positive group was separated into 3 subgroups according to bacterial intensity such as HP (+) (n=40), HP (++) (n=40), HP (+++) (n=40). Results: The serum LDL, TC levels, TC/HDL, LDL/HDL, Non-HDL cholesterol, Non-HDL cholesterol/HDL indexes were significantly higher in the HP positive group compared to the HP negative group. As the severity of HP increased among the HP (+), HP (++), HP (+++) subgroups, a significant difference was found in all investigated lipid parameters; TC, LDL, TG, AIP, TG / HDL, TC / HDL, LDL / HDL, Non-HDL cholesterol, Non-HDL cholesterol/HDL were higher (p=0.001; 0.001; 0.035; 0.012; 0.012; 0.001; 0.001; 0.001; 0.001 respectively), HDL level was lower (p=0.002). Conclusion: The presence and severity of HP infection in diabetics affects all lipid profile parameters except TG and TG-containing rates, therefore HP infection impacts the lipid profile atherogenically in diabetic patients.