Akademik Veri Yönetim Sistemi
JOURNAL OF HEALTH SCIENCES AND MEDICINE, cilt.4, sa.5, ss.675-679, 2021 (Hakemli Dergi)
ABSTRACT
Aim: To evaluate the clinical manifestations, histopathologic composition, and demographic characteristics of the lymphomas
presented in the head and neck.
Material and Method: Records of subjects who had a diagnosis of lymphoma by an otolaryngology clinic in a tertiary referral
hospital between May 2007 and July 2017 were reviewed. Demographic features and data regarding histopathology, radiology,
and clinical presentation were evaluated.
Results: A total of 103 lymphomas in the head and neck region, 79 (77%) nodal lymphoma, and 24 (23%) extranodal
lymphoma, were diagnosed. The initial presentation was solitary lymphadenopathy in 12 (15%) of the nodal lymphomas but
conglomerated or multiple lymphadenopathies in the others. No significant relationship was found between lymph node size
and histopathology (p=0.144). Extranodal lymphomas presented most commonly in tonsils (n=8, 33%). Hodgkin lymphoma
to non-Hodgkin lymphoma ratio was 0.8 (35/44) among nodal lymphomas. The dominant subgroup of non-Hodgkin
lymphomas was diffuse large b-cell lymphoma (n=18, 40%). All of the Hodgkin lymphomas in our series were classic variant,
and the subjects were younger than the non-Hodgkin lymphomas (z=-4.803, p<0.001). The histopathology of 46 (68%) of
non-Hodgkin lymphomas was aggressive. T/NK-cell NHL was detected in seven subjects (6.8%). This was the only group with
male predominance (n=5, 71%).
Conclusion: Lymphomas are a large group of malignancies that can present in various clinical forms in the head and neck
region. The gender and age of onset of this neoplasm differ by many biological, environmental, and epidemiological factors.
Ultrasound findings are crucial in evaluating suspicious lymph nodes. A tissue biopsy is recommended to exclude lymphomas
from other neoplasms to make an accurate diagnosis.
Keywords: Lymphoma, head and neck, malignancy