Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC

Degim, T; Akay, C; Buyukafsar, K; Cevheroglu, S

doi:10.1016/s0731-7085(01)00392-2

Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC

Atıf İçin Kopyala

Degim T., Akay C., Buyukafsar K., Cevheroglu S.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.26, sa.1, ss.15-21, 2001 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 26 Sayı: 1
Basım Tarihi: 2001
Doi Numarası: 10.1016/s0731-7085(01)00392-2
Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.15-21
Gazi Üniversitesi Adresli: Hayır

Özet

A reverse phase high performance liquid chromatography (HPLC) method was developed for the simultaneous determination or codeine (methyl morphine) and dionin (ethyl morphine hydrochloride) in antitussive analgesic tablet formulations. A C-18 column and methanol-water (1:2) mixture mobile phase (pH 3.0) were used. Spectrophotometric detection was carried out at 210 nm. The total elution time was shorter than 7 min. This method was found to be quite precise and reproducible. This proposed method was successfully applied to the determination of codeine and ethyl morphine hydrochloride in tablets produced by the Turkish Army Drug Factory. (C) 2001 Elsevier Science B.V. All rights reserved.