Comparison of the Effects of Dexmedetomidine vs. Ketamine in Cardiac Ischemia/Reperfusion Injury in Rats - Preliminary Study

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Guler L., Bozkirli F., BEDİRLİ N., ÜNAL Y., Guler A., ER ÖZTAŞ Y., ...Daha Fazla

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, cilt.23, sa.5, ss.683-689, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.17219/acem/37214
  • Dergi Adı: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.683-689
  • Anahtar Kelimeler: dexmedetomidine, ketamine, cardiac ischemia/reperfusion injury, ISCHEMIA-REPERFUSION INJURY, MYOCARDIAL BLOOD-FLOW, GLUTATHIONE-PEROXIDASE, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, S(+)-KETAMINE, SEVOFLURANE, ANESTHESIA, SURGERY, MODEL
  • Gazi Üniversitesi Adresli: Evet

Özet

Objectives. Following ischemia/reperfusion injury, antioxidant defense mechanisms may remain insufficient depending on the duration of ischemia which is caused by any reason (MI, after percutaneous coronary intervention, during cardiac surgery). After that, free oxygen radicals increasing within the cell cause structural deterioration. Cytokines which activate a series of reactions that cause tissue damage and inflammatory response are released during reperfusion of ischemic tissues. In this study, we aimed to compare the effects of dexmedetomidine and ketamine in cardiac ischemia/reperfusion injury.