Synthesis and acetylcholinesterase/butyrylcholinesterase inhibitory activities of (substituted/nonsubstituted benzal)hydrazone derivatives of 3-(6-substituted-3(2h)-pyridazinon-2- yl)propionohydrazides


ÖZÇELİK A. B. , Gókçe M., Orhan İ. , ŞAHİN M. G.

Fabad Journal of Pharmaceutical Sciences, cilt.35, sa.3, ss.153-161, 2010 (Diğer Kurumların Hakemli Dergileri) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Konu: 3
  • Basım Tarihi: 2010
  • Dergi Adı: Fabad Journal of Pharmaceutical Sciences
  • Sayfa Sayıları: ss.153-161

Özet

In this study thirteen new substituted/nonsubstituted benzalhydrazone V derivatives of 3-(6-substituted-3(2H)-pyridazinon- 2-yl)propionohydrazide derivatives IV were synthesized as acetylcholinesterase and butyrylcholinesterase inhibitors. The structures of compounds V were elucidated by IR, 1H-NMR and MASS spectra. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChe) inhibitory activity of V derivatives was measured using Ellman's method. Only (4-chlorophenylbenzal)hydrazone derivatives of 3-(6-(4-fluorophenyl)-3(2H)-pyridazinon-2-yl)propionohydrazide Vi showed an excellent inhibitory effect against AChE. In addition, Vi showed a significant inhibitory effect against BChE.