A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies


Bozbey İ., Özdemir Z., Uslu H., Özçelik A. B. , Şenol Deniz F. S. , Erdoğan Orhan İ., ...More

MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol.20, no.11, pp.1042-1060, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 11
  • Publication Date: 2020
  • Doi Number: 10.2174/1389557519666191010154444
  • Journal Name: MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1042-1060
  • Keywords: Alzheimer's disease, AChE inhibitor, BChE inhibitor, 3(2H)-Pyridazinone, hydrazone, molecular docking, ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, DESIGN, INHIBITION, NARINGENIN, ANALOGS, COMPLEX, MTDLS
  • Gazi University Affiliated: Yes

Abstract

Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulation of cognition in animals. Inhibition of cholinesterases is an effective method to curb Alzheimer's disease, a progressive and fatal neurological disorder.