A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies

Bozbey İ., Özdemir Z., Uslu H., Özçelik A. B., Şenol Deniz F. S., Erdoğan Orhan İ., ...Daha Fazla

MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.20, sa.11, ss.1042-1060, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 11
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1389557519666191010154444
  • Dergi Adı: MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1042-1060
  • Anahtar Kelimeler: Alzheimer's disease, AChE inhibitor, BChE inhibitor, 3(2H)-Pyridazinone, hydrazone, molecular docking, ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, DESIGN, INHIBITION, NARINGENIN, ANALOGS, COMPLEX, MTDLS
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulation of cognition in animals. Inhibition of cholinesterases is an effective method to curb Alzheimer's disease, a progressive and fatal neurological disorder.