Akademik Veri Yönetim Sistemi
JOURNAL OF APPLIED TOXICOLOGY, 2026 (SCI-Expanded, Scopus)
The need to increase agricultural productivity due to population growth and rising food demand has led to the widespread use of pesticides, which are significant environmental pollutants that contribute to bioaccumulation in the food chain. Among pesticides, insecticides have effects not only on insecticides but also on non-target organisms. One of the insecticides, diflubenzuron, is a chitin synthesis inhibitor that is effective against both agricultural pests and public health pests such as mosquitoes. The present study aimed to investigate the biochemical effects of diflubenzuron on non-target organisms, scorpion (Aegaeobuthus gibbosus). After exposure to 1 and 10 mg/L diflubenzuron for 96 h, the hemolymph fluid and muscles (femur and telson) were sampled to analyze oxidative stress parameters. Total antioxidant status and total oxidative stress levels in the hemolymph fluid were altered significantly (p < 0.05). In telson muscles, superoxide dismutase activity was significantly reduced after 10 mg/L diflubenzuron exposure, while catalase and glutathione peroxidase activities increased (p < 0.05). A significant increase in catalase and glutathione peroxidase activities was observed in femur muscle tissue (p < 0.05). This study demonstrates that diflubenzuron, a chitin synthesis inhibitor, has strong metabolic and oxidative toxic effects on scorpions. These effects suggest that diflubenzuron may pose a significant toxicity risk to non-target arthropods and that its use in pest control should be re-evaluated in terms of potential side effects on the ecosystem.