Bioactive self-assembled peptide nanofibers for corneal stroma regeneration

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Uzunalli G., Soran Z., Erkal T. S., Dagdas Y. S., Dinc E., Hondur A. M., ...Daha Fazla

ACTA BIOMATERIALIA, cilt.10, sa.3, ss.1156-1166, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.actbio.2013.12.002
  • Dergi Adı: ACTA BIOMATERIALIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1156-1166
  • Anahtar Kelimeler: Corneal stroma regeneration, YIGSR, RGD, Peptide amphiphile, Self-assembly, RECOMBINANT HUMAN COLLAGEN, EXTRACELLULAR-MATRIX, CHONDROITIN SULFATE, IN-VITRO, TISSUE, DIFFERENTIATION, RGD, IMPLANTATION, GROWTH, CELLS
  • Gazi Üniversitesi Adresli: Evet

Özet

Defects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential for treatment of these defects. This paper describes a bioactive peptide nanofiber scaffold system for corneal tissue regeneration. These nanofibers are formed by self-assembling peptide amphiphile molecules containing laminin and fibronectin inspired sequences. Human corneal keratocyte cells cultured on laminin-mimetic peptide nanofibers retained their characteristic morphology, and their proliferation was enhanced compared with cells cultured on fibronectin-mimetic nanofibers. When these nanofibers were used for damaged rabbit corneas, laminin-mimetic peptide nanofibers increased keratocyte migration and supported stroma regeneration. These results suggest that laminin-mimetic peptide nanofibers provide a promising injectable, synthetic scaffold system for cornea stroma regeneration. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.