COMPARISON OF BIOCHEMICAL MARKERS BEFORE AND AFTER BARIATRIC SURGERY

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Ünal K., Ibrahimkahanlı L., Göbüt H., Büyükkasap A. Ç.

International Biochemistry Congreess 2023 // 34th National Biochemistry Congress , Muğla, Türkiye, 29 Ekim - 01 Kasım 2023

  • Yayın Türü: Bildiri / Yayınlanmadı
  • Basıldığı Şehir: Muğla
  • Basıldığı Ülke: Türkiye
  • Gazi Üniversitesi Adresli: Evet

Özet

COMPARISON OF BIOCHEMICAL MARKERS BEFORE AND AFTER BARIATRIC SURGERY
Kübranur Ünal1, Leyla İbrahimkhanlı1, Hüseyin Göbüt2, Ahmet Çağrı Büyükkasap2
1 Gazi University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Türkiye
2 Gazi University, Faculty of Medicine, Department of General Surgery, Ankara, Türkiye
Objectives: Bariatric surgery is one of the most effective strategies in the treatment of obesity and obesity-related diseases. It is known that there are significant changes in patients after surgery. The aim of this study is to compare biochemical markers in patients before and after bariatric surgery.
Material and Methods: Pre and postoperative (after 3 months)  serum levels of biochemical markers of 40 (24 female / 16 male) bariatric surgery patients were reviewed retrospectively. The data were described using a median (25–75% IQR).
Results:  When the before and after surgery test results were compared,  it was observed that the levels of fasting blood glucose decreased statistically from  95 (87,5-117,5) to 90 (81,25-99,75), insulin from 13,45 (8,72-23,07) to 6,60 (4,35-8,95), HOMA from 3,25 (2,5-5,75) to 1,6 (0,9-2,07), C peptide from 3,45 (2,62-4,77) to 2,4 (1,7-3,22), triglycerides from 141 (112,75-179,25) to 113 (93-149,25), LDL cholesterol from  123,8 (103,1-151) to 106,8 (84,45-125,9), HDL cholesterol from 49 (43-56,75) to 41 (38-46), total cholesterol from 205 (184,25-229,25) to 167 (148-190,75) and T3 from 3,7 (3,3-3,9) to 3,3(3,2-3,7)  in the postoperative group.(p < .001)  While the levels of osteocalcin increased statistically from 3 (2-4) to 4 (2-5), cortisol from 11,82 (8,98 -14,13) to 13,24  (11,4-15,2), T4 from 0,88 (0,8-0,95) to 0,95 (0,89-1,05) and ferritin from  23(10,25-63) to 27,5(13,25-89,25)  in the postoperative group.(p < .001)
Conclusion: It is important to review the levels of routine biochemical markers in predicting the positive and negative effects of bariatric surgery in the early stages. More advanced studies are needed to determine the late-stage effects of bariatric surgery.