Effects of epidermal growth factor in artificial tear on vitamin C levels of corneal wounded eye tissues
EYE, cilt.15, ss.213-216, 2001 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15
- Basım Tarihi: 2001
- Doi Numarası: 10.1038/eye.2001.64
- Dergi Adı: EYE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.213-216
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
Purpose To investigate the effect of artificial tear (AT) solution and epidermal growth factor (EGF) treatment on the cornea and aqueous humour ascorbic acid (AA) levels of full-thickness conceal wounded eyes. Methods The effect of EGF on the AA levels of aqueous humour and conceal wound tissue was determined in full-thickness conceal wounded rabbit eyes on the seventh postoperative day. There were three groups: untreated controls, AT-treated controls and an EGF+AT-treated experimental group (n = 6 in each group). Conceal wounded eyes were topically treated with 5 mul AT or 5 mul EGF in AT (1 mg/l EGF in AT prepaaration which contained 3.0% carbopol 940) twice daily for 6 days after operation. The wound strengths were also measured on the seventh postoperative day as a measure of wound healing. Statistical analysis was carried out using the Mann-Whitney U-test by Statview program. Results The wound strengths of corneas, and AA levels of wound tissues and aqueous humour, increased significantly following AT and EGF treatment (p < 0.05). Conclusion In the conceal wounded eye, aqueous humour serves as a source of vitamin C and there may be a relation between EGF treatment in AT and AA levels of corneal wounded eye tissues.