Analgesic activity of Cistus laurifolius in mice

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Ark M., Ustun O., Yesilada E.

PHARMACEUTICAL BIOLOGY, cilt.42, sa.2, ss.176-178, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/13880200490512250
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.176-178
  • Anahtar Kelimeler: analgesic activity, Cistus laurifolius, Cistaceae, chloroform extract
  • Gazi Üniversitesi Adresli: Hayır

Özet

The possible analgesic activity of Cistus laurifolius extracts has been evaluated by using tail flick and acetic acid-induced writhing tests in mice. The chloroform extract (500 mg/kg, i.p.) and the precipitated fraction (10, 30, 100 mg/kg, i.p.) obtained from C laurifolius leaves showed significant analgesic activity on tail flick assay, while aqueous, ethanol and butanol extracts of the plant had no activity on the same test. Chloroform extract (500 mg/kg, i.p.) and precipitate fraction (30 mg/kg, i.p.) also inhibited number of writhings induced by acetic acid. These observations suggest that C. laurifolius leaves possess antinociceptive compound(s) which act through a central mechanism.