Analgesic activity of Cistus laurifolius in mice

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Ark M., Ustun O., Yesilada E.

PHARMACEUTICAL BIOLOGY, vol.42, no.2, pp.176-178, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1080/13880200490512250
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.176-178
  • Keywords: analgesic activity, Cistus laurifolius, Cistaceae, chloroform extract
  • Gazi University Affiliated: No


The possible analgesic activity of Cistus laurifolius extracts has been evaluated by using tail flick and acetic acid-induced writhing tests in mice. The chloroform extract (500 mg/kg, i.p.) and the precipitated fraction (10, 30, 100 mg/kg, i.p.) obtained from C laurifolius leaves showed significant analgesic activity on tail flick assay, while aqueous, ethanol and butanol extracts of the plant had no activity on the same test. Chloroform extract (500 mg/kg, i.p.) and precipitate fraction (30 mg/kg, i.p.) also inhibited number of writhings induced by acetic acid. These observations suggest that C. laurifolius leaves possess antinociceptive compound(s) which act through a central mechanism.