Central giant cell granuloma (CGCG) is a relatively uncommon benign intraosseous lesion comprising for less than 7% of all benign lesions of the jaws. CGCG is seen more frequently in mandible than maxilla and in females than males. Patients are generally younger than 30 years. The clinical behavior of the lesion varies from an asymptomatic osteolytic lesion that grows slowly, to an aggressive, painful process accompanied by teeth resorption, cortical bone destruction. Aetiology of CGCG is still unclear, although haemorrhage, inflammation, genetic and local trauma have been considered.