Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer Patients Perioperatif Tedavi Görmüş Mide Kanseri Hastalarında Yeni Bir İmmünonutrisyonel Belirteç Olarak CALLY İndeksi Değerlendirilmesi

AKDOĞAN O., Yücel K. B., YAZICI O., ÖZET A., ÖZDEMİR N.

Gazi Medical Journal, cilt.36, sa.1, ss.85-90, 2025 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.12996/gmj.2024.4197
  • Dergi Adı: Gazi Medical Journal
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.85-90
  • Anahtar Kelimeler: albumin, CALLY index, CRP, Gastric cancer, lymphocyte, prognostic
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: This study aimed to investigate the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in patients with early-stage gastric cancer and compare it with other immune markers, such as systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), and prognostic nutritional index (PNI). Methods: We retrospectively analyzed patients with early-stage gastric cancer who received adjuvant or perioperative chemotherapy. Laboratory results were obtained from the preoperative period. The CALLY index was calculated as follows: serum albumin level (g/dL) x absolute lymphocyte counts (109/L) / CRP (mg/dL) x104. Results: A total of 74 patients were included in the study. The median relapse-free survival (RFS) was 13.0 (95 %CI: 7.7-18.2) months in the low CALLY index group and 38.2 (95% CI:18.4-57.8) months in the high CALLY index group (p<0.001). The median overall survival (OS) was 25.0 (95% CI: 17.1-32.8) months in the low CALLY index group and 60.4 (95% CI:45.8-74.1) months in the high-CALLY-index group (p<0.001). In multivariate cox regression analyses, a low CALLY index was an independent risk factor for both relapse-free survival (RFS) and OS. Conclusion: The CALLY index was a prognostic factor for both RFS and OS, with a higher prognostic value than other prognostic factors (NLR, PNI, SII).