Glyco-nanoparticles: New drug delivery systems in cancer therapy

Khan H., Mirzaei H. R. , Amiri A., AKKOL E. , Halimi S. M. A. , Mirzaei H.

SEMINARS IN CANCER BIOLOGY, cilt.69, ss.24-42, 2021 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 69
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.semcancer.2019.12.004
  • Sayfa Sayıları: ss.24-42


Cancer is known as one of the most common diseases that are associated with high mobility and mortality in the world. Despite several efforts, current cancer treatment modalities often are highly toxic and lack efficacy and specificity. However, the application of nanotechnology has led to the development of effective nanosized drug delivery systems which are highly selective for tumors and allow a slow release of active anticancer agents. Different Nanoparticles (NPs) such as the silicon-based nano-materials, polymers, liposomes and metal NPs have been designed to deliver anti-cancer drugs to tumor sites. Among different drug delivery systems, carbohydratefunctionalized nanomaterials, specially based on their multi-valent binding capacities and desirable biocompatibility, have attracted considerable attention as an excellent candidate for controlled release of therapeutic agents. In addition, these carbohydrate functionalized nano-carriers are more compatible with construction of the intracellular delivery platforms like the carbohydrate-modified metal NPs, quantum dots, and magnetic nano-materials. In this review, we discuss recent research in the field of multifunctional glycolnanoparticles (GNPs) intended for cancer drug delivery applications.