The Effect of Temozolomide on the Prevention of Epidural Fibrosis Developing after Lumbar Laminectomy in Rats

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Aydincak O., Yilmaz M. B., Emmez H., KURT G., SEPİCİ DİNÇEL A., Memis L., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.22, sa.6, ss.706-711, 2012 (SCI-Expanded, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5137/1019-5149.jtn.5966-12.1
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.706-711
  • Anahtar Kelimeler: Temozolomide, Epidural fibrosis, Anti-proliferative drug, Laminectomy, Failed back surgery syndrome, MITOMYCIN-C, PERIDURAL FIBROSIS, SCAR FORMATION, ADCON-L, SURGERY, MODEL, 5-FLUOROURACIL, INHIBITION, REDUCTION
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Gazi Üniversitesi Adresli: Evet

Özet

AIM: Failed back surgery syndrome is observed in 15% of patients who have undergone surgery for lumbar disk hernia. Excess epidural fibrosis is the etiology in 24% of FBSS cases. This study was conducted with the belief that the antiproliferative effect of temozolomide can prevent epidural fibrosis.