Analysis of insulin like growth factor 1 and insulin like growth factor binding protein 3 levels in bronchoalveolar lavage fluid and serum of patients with lung cancer

Unsal E., KÖKSAL D., Yurdakul A., Atikcan S., Cinaz P.

RESPIRATORY MEDICINE, cilt.99, sa.5, ss.559-565, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 99 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.rmed.2004.10.012
  • Dergi Adı: RESPIRATORY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.559-565
  • Anahtar Kelimeler: IGF-1, IGFBP-3, Bronchoalveolar lavage, lung cancer, FACTOR-BINDING-PROTEINS, FACTOR-I, FACTOR (IGF)-I, PLASMA-LEVELS, LIFE-STYLE, RISK, MEN
  • Gazi Üniversitesi Adresli: Hayır

Özet

Objective: Insulin like growth factor 1 (IGF-1) is recognized as a potent mitogen for many cancer cell lines and there is good evidence that lung cancer cells produce both IGF-1 and insulin like growth factor binding protein 3 (IGFBP-3). The aim of this study was to investigate the clinical significance of IGF-1 and IGFBP-3 levels in serum and in bronchoalveolar lavage (BAL) fluid by comparing lung cancer patients with healthy controls.