Effects of rosiglitazone treatment on the pentose phosphate pathway and glutathione-dependent enzymes in liver and kidney of rats fed a high-fat diet


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Akbay E., Ulusu N., Toruner F., Ayvaz G., Taneri F., Akturk M., ...More

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.65, no.1, pp.79-89, 2004 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1016/s0011-393x(04)90007-0
  • Title of Journal : CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Page Numbers: pp.79-89
  • Keywords: rosiglitazone, pentose phosphate pathway, glutathione-dependent metabolism, metabolic syndrome, high-fat diet, rat, obesity, PEROXISOME PROLIFERATORS, ANTIOXIDANT ENZYMES, LIPID-PEROXIDATION, OXIDATIVE STRESS, RECEPTOR-GAMMA, TROGLITAZONE, PURIFICATION, HEPATOCYTES, MECHANISMS, LEPTIN

Abstract

Background: Animals fed high-fat diets have been shown to develop hyperglycemia, insulin resistance, hyperlipidemia, and moderate obesity, which resemble the human metabolic syndrome. Obesity, the metabolic syndrome, and some thiazolidinediones, which act as insulin sensitizers, may increase oxidative stress, and/or influence the levels of cellular reducing equivalents and homeostasis.