CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.65, no.1, pp.79-89, 2004 (Journal Indexed in SCI)
Article / Article
Title of Journal :
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
rosiglitazone, pentose phosphate pathway, glutathione-dependent metabolism, metabolic syndrome, high-fat diet, rat, obesity, PEROXISOME PROLIFERATORS, ANTIOXIDANT ENZYMES, LIPID-PEROXIDATION, OXIDATIVE STRESS, RECEPTOR-GAMMA, TROGLITAZONE, PURIFICATION, HEPATOCYTES, MECHANISMS, LEPTIN
Background: Animals fed high-fat diets have been shown to develop hyperglycemia, insulin resistance, hyperlipidemia, and moderate obesity, which resemble the human metabolic syndrome. Obesity, the metabolic syndrome, and some thiazolidinediones, which act as insulin sensitizers, may increase oxidative stress, and/or influence the levels of cellular reducing equivalents and homeostasis.