Effects of rosiglitazone treatment on the pentose phosphate pathway and glutathione-dependent enzymes in liver and kidney of rats fed a high-fat diet.

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Akbay E., Ulusu N., Toruner F. S., Ayvaz G., Taneri F., Akturk M. Y., ...Daha Fazla

Current therapeutic research, clinical and experimental, cilt.65, sa.1, ss.79-89, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/s0011-393x(04)90007-0
  • Dergi Adı: Current therapeutic research, clinical and experimental
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.79-89
  • Anahtar Kelimeler: rosiglitazone, pentose phosphate pathway, glutathione-dependent metabolism, metabolic syndrome, high-fat diet, rat, obesity, PEROXISOME PROLIFERATORS, ANTIOXIDANT ENZYMES, LIPID-PEROXIDATION, OXIDATIVE STRESS, RECEPTOR-GAMMA, TROGLITAZONE, PURIFICATION, HEPATOCYTES, MECHANISMS, LEPTIN
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Animals fed high-fat diets have been shown to develop hyperglycemia, insulin resistance, hyperlipidemia, and moderate obesity, which resemble the human metabolic syndrome. Obesity, the metabolic syndrome, and some thiazolidinediones, which act as insulin sensitizers, may increase oxidative stress, and/or influence the levels of cellular reducing equivalents and homeostasis.