Synthesis, characterization and antioxidant and antimicrobial properties of new ester and amide derivatives of indole-2-carboxylic acid

BAYTAŞ S., Inceler N., Orhan D. D., Ozkan S.

Fabad Journal of Pharmaceutical Sciences, cilt.36, sa.2, ss.53-61, 2011 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 2
  • Basım Tarihi: 2011
  • Dergi Adı: Fabad Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.53-61
  • Anahtar Kelimeler: Antimicrobial activity, Chelating activity, DPPH, Indole, Reducing power
  • Gazi Üniversitesi Adresli: Evet

Özet

New ester and amide derivatives of indole-2-carboxylic acid (1-6) were synthesized and evaluated for their in vitro antioxidant and antimicrobial properties. The compounds 5 and 6 demonstrated scavenging effect against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. These two compounds showed excellent reducing power at 200, 150, 100 and 50 μg/ml concentrations as compared to butylated hydroxytoluene (BHT). All tested compounds also exhibited more powerful Fe2+ chelating activity than Ethylenediaminetetraacetic acid (EDTA). With regard to antimicrobial properties, compound 2 was most active derivative against Enterococcus faecalis and also demonstrated significant activity against Candida albicans with a MIC value of 8 μg/mL. Compounds 1, 3, 5 and 6 had noticeable antifungal activities against C. albicans.