Antitumor activity of gemcitabine hydrochloride loaded lipid polymer hybrid nanoparticles (LPHNs): In vitro and in vivo

YALÇIN T. E., İLBASMIŞ TAMER S., TAKKA S.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.580, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 580
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.ijpharm.2020.119246
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Gemcitabine hydrochloride, Lipid polymer hybrid nanoparticles, Pharmacokinetics, Cytotoxicity, Anti-tumor activity, BREAST-CANCER, DELIVERY, NANOMEDICINE, LIPOSOMES, PACLITAXEL, RESISTANCE, DOCETAXEL, THERAPY, RELEASE
  • Gazi Üniversitesi Adresli: Evet

Özet

The present study demonstrated the application of gemcitabine hydrochloride (GEM) loaded lipid polymer hybrid nanoparticles (LPHNs) for the enhancement the chemotherapeutic response. GEM, which is an anti-tumor drug, is frequently utilized for the treatment of non-small cell lung cancer, breast cancer and pancreatic cancer. GEM loaded LPHNs were formed and examined for pharmacokinetic profile and in vivo anticancer activity. Modified double emulsion solvent evaporation method was employed in the preparation of the LPHNs. Cytotoxicities of the GEM loaded LPHNs formulation were evaluated on MCF-7 and MDA-MB-231 cells by MTT assays. Pharmacokinetics and in vivo anticancer efficacy studies were conducted following intraperitoneal administration in female Sprague-Dawley rats.