Does adenosine deaminase activity play a role in the early diagnosis of ectopic pregnancy?

Turkmen G., Karçaaltincaba D., Işik H., Fidanci V., Kaayalp D., Timur H., ...More

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, no.3, pp.347-350, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2016
  • Doi Number: 10.3109/01443615.2015.1065228
  • Journal Name: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.347-350
  • Keywords: Adenosine deaminase, ectopic pregnancy, pregnancy complications
  • Gazi University Affiliated: Yes

Abstract

Early diagnosis of ectopic pregnancy (EP) is important due to life-threatening consequences in the first trimester of pregnancy. In this study we aimed to investigate the role of adenosine deaminase (ADA) activity in the prediction of EP. Forty-one patients with unruptured ectopic pregnancy comprised the case group and forty-two first trimester pregnant women with shown foetal heart beating in ultrasound comprised the control group. The mean ADA level in EP (10.9 +/- 3.0 IU/L) was higher than that in control group (9.2 +/- 3.6 IU/L) (p = 0.018). Receiver operating characteristics or ROC curve identified ADA value of 10.95 IU/L as optimal threshold for the prediction of EP with 56% sensitivity and 67% specificity. High ADA levels are valuable in the early diagnosis of EP. However more comprehensive studies are required.